Animal models of pain: Diversity and benefits

Chronic pain is a maladaptive neurological disease that remains major health problem. A deepening of our knowledge on mechanisms cause prerequisite to developing novel treatments. large variety animal models has been developed recapitulate the diverse symptoms different pathologies. These reproduce phenotypes and remain necessary examine multidimensional aspects understand cellular molecular basis underlying conditions. In this review, we propose an overview models, from simple organisms rodents non-human primates specific traits pathologies they model. We present main behavioral tests for assessing investing underpinning chronic pathological pain. The validity analysed based their ability mimic human clinical diseases predict treatment outcomes. Refine characterization also requires consider globally using procedures dedicated study emotional comorbidities discuss limitations when research findings fail be translated clinics. But point some recent successes in analgesic drug development highlight strategies improving predictive Finally, emphasize importance assortments preclinical identify subtype mechanisms, foster better analgesics.